Iovera is a non-opioid, FDA-cleared medical treatment that uses extreme cold (cryoneurolysis) via a handheld device to temporarily block pain signals from specific nerves, offering immediate relief for conditions like knee osteoarthritis (OA) or pain from knee replacement surgery, with effects lasting up to 90 days as nerves regenerate. It’s a needle-based procedure that freezes targeted nerves without permanent damage, reducing opioid reliance and improving mobility, and can also treat pain in other areas like the hip, shoulder, and spine.